KMID : 0828520130170040198
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Journal of the Korean Geriatrics Society 2013 Volume.17 No. 4 p.198 ~ p.204
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The Features and Prognoses in Organophosphate Intoxication according to Age
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Lim Seung-Wook
Park Seung-Min Lee Young-Hwan Lee Won-Woong Ahn Ji-Yun Son Yoo-Dong Ahn Hee-Cheol Kim Hyun
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Abstract
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Background: The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and the differences between the elderly (¡Ã65 years) and younger adults (18-64 years) looking at vital sign, length of admission, cholinesterase activity, complications, and prognosis.
Methods: All patients visiting one Emergency Department (ED) with organophophate intoxication between January 2000 and December 2011 were reviewed retrospectively. We divided the patients into two groups, geriatric adults (¡Ã 65 years) and nongeriatric adults (18-64 years).
Results: During the study period, 155 patients (45 patients, ¡Ã65 years; 110 patients, 18-64 years) presented to the ED with organophosphate intoxication. Thirty-six elderly patients (80.0%) vs. 63 younger adult patients (57.3%) were intubated endotracheally, with the analysis showing a clear distinction between the two groups (p=0.026). Twenty-two elderly patients (48.9%) vs. 23 younger adult patients (20.9%) went into shock, displaying a significant gap (p=0.008). Thirtyfive elderly patients (81.4%) vs. 62 younger adult patients (59.0%) developed respiratory complications and 20 elderly patients (46.5%) vs. 19 younger adult patients (18.1%) developed central nervous system complications, with obvious differences seen in each of the comparison at (p=0.031) and (p=0.005), respectively. Comparing plasma cholinesterase levels at 1st, 3rd, 5th, 10th, 15th, and 20th days, the rate of increase was faster in the younger adults (p=0.022).
Conclusion: With organophosphate intoxication, elderly patients tended to be intubated endotracheally, went into shock, developed central nervous system complications, were more severe, and showed a slower increase in cholinesterase level.
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KEYWORD
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Cholinesterases, Aged, Organophosphate poisoning
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